Formic Acid → Methyl 5-formyl-3-methylthiophene-2-carboxylate
Reaktionsgleichung
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:11](OCC)[O:12]CC)=[CH:8][C:9]=1[CH3:10])=[O:4].C(O)=O>O1CCOCC1>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:11]=[O:12])=[CH:8][C:9]=1[CH3:10])=[O:4]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
A solution of 5-diethoxymethyl-3-methyl-thiophene-2-carboxylic acid methyl ester (4.41 g, 17.1 mmol) in dioxane (20 ml) was cooled to 0° C. (ice bath). 88% formic acid (40 ml) was added in one portion and the mixture was stirred at 0° C. for 5 min and then at rt for 30 min. The mixture was concentrated under reduced pressure to afford the desired product which was not further purified (3.2 g, 100% yield).
Aufarbeitung
- waitat rt for 30 min
- concentrationThe mixture was concentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-acb7632ba7dc4176b05e09c2efa6667f
- Quelldatensatz
- uspto-grants-2013_03
- Patentnummer
- US08404859B2
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