Lithium hydroxide, monohydrate → HCID 178524764, Verbindung
Reaktionsgleichung
O[Li].O.[OH:4][C:5]1[C:10]([C:11]([O:13]C)=[O:12])=[CH:9][N:8]=[CH:7][N:6]=1>O.O1CCCC1>[OH:4][C:5]1[C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=[CH:7][N:6]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The moist sodium salt of methyl 4-hydroxypyrimidine-5-carboxylate obtained as in Example 2a) was taken up in water/tetrahydrofuran=1:1, and 1.0 eq of LiOH.H2O was added. Following hydrolysis of the ester over 3.5 hours at 0° C. and 2 hours at room temperature, most of the tetrahydrofuran was evaporated and, at 0° C., a pH of 3 was adjusted using eq. HCl solution. After about 45 minutes at 0° C., the title product was filtered off. Drying gave the acid in a yield of 3.55 g (78%).
Aufarbeitung
- additionwas added
- custom2 hours at room temperature, most of the tetrahydrofuran was evaporated and, at 0° C.
- filtrationthe title product was filtered off
- customDrying
- customgave the acid in a yield of 3.55 g (78%)
Quellen und Nachweise
- ORD-Eintrag
- ord-bf7b8571eb4f4372a70f6bb8fc3b029e
- Quelldatensatz
- uspto-grants-2000_09
- Patentnummer
- US06114527
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