Ethanol → HCID 23298086, Verbindung

HRID 1953413Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1953413
C(N[C:5]1[C:10](/[CH:11]=[CH:12]/[C:13]2[CH:14]=[C:15]([NH:19][C:20]3[C:25]([NH2:26])=[CH:24][CH:23]=[CH:22][N:21]=3)[CH:16]=[CH:17][CH:18]=2)=[CH:9][CH:8]=[CH:7][N:6]=1)(=O)C.[Cl-].[NH4+:28].[CH2:29]([OH:31])[CH3:30]>[Fe].O>[C:29]([NH:28][C:7]1[N:6]=[CH:5][C:10](/[CH:11]=[CH:12]/[C:13]2[CH:14]=[C:15]([NH:19][C:20]3[C:25]([NH2:26])=[CH:24][CH:23]=[CH:22][N:21]=3)[CH:16]=[CH:17][CH:18]=2)=[CH:9][CH:8]=1)(=[O:31])[CH3:30]

Komponenten

6

Edukt 3

HCID 702EthanolHCID 25517Ammonium ChlorideHCID 232980872-[3-[(E)-2-(2-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine

Produkt 1

HCID 23298086HCID 23298086, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 2-[3-[(E)-2-(2-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine (1.86 g), iron powder (1.39 g) and ammonium chloride (0.26 g), ethanol (20 ml) and water (6 ml) was stirred under reflux for an hour. The reaction was filtered, concentrated and extracted with chloroform. The extracts were washed with saturated sodium bicarbonate solution, dried and evaporated to afford 2-[3-[(E)-2-(6-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine as dark purple crystals (1.59 g).

Aufarbeitung

  1. temperatureunder reflux for an hour
  2. filtrationThe reaction was filtered
  3. concentrationconcentrated
  4. extractionextracted with chloroform
  5. washThe extracts were washed with saturated sodium bicarbonate solution
  6. customdried
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-72f7a37a2ca0483ba7f2a2b1bb9946e1
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06117875

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