Benzyl Bromide → 1,3-Diphenylmethyl-2-piperidinone

Temperatur

-78 °C

1-Phenylmethyl-2-piperidinone (See: Yamaguchi M, Hirao I (1985) "A direct synthesis of [(tert-butoxycarbonyl)methylidene]-azacycloalkanes from N-alkyllactams" J. Org. Chem., 50, 1975-1977) (3.40 g, 18 mmol) was reacted with benzyl bromide (4.84 g, 28.3 mmol) in the presence of lithium diisopropylamide (prepared by treating diisopropylamine (2.73 g, 27 mmol) with butyllithium in hexanes (2.5M, 10.3 mL, 25.7 mmol)) in THF (45 mL) and HMPA (2.7 mL, 15.5 mmol) as described above in the preparation of Example 7. After the addition of benzyl bromide, the reaction mixture was stirred for 2 h at -78° C., and then quenched with saturated NH4Cl (50 mL). The reaction mixture was extracted with ether (3×40 mL) and the combined ether extract washed with brine (40 mL) and dried over MgSO4. The solvent was removed in vacuo, and the residue (8.40 g) thus obtained, was chromatographed over silica gel (hexanes-CHCl3 -EtOAC, 15:4:1 and then 7:2:1) to give the product lactam (3.14 g, 63%) as a colorless solid: mp 94°-95° C. (CH2Cl2 -hexanes).

1. customas described above in the preparation of Example 7
2. customquenched with saturated NH4Cl (50 mL)
3. extractionThe reaction mixture was extracted with ether (3×40 mL)
4. extractionthe combined ether extract
5. washwashed with brine (40 mL)
6. dry with materialdried over MgSO4
7. customThe solvent was removed in vacuo

ORD-Eintrag

ord-36873489219e434fb22990ced8c9c43f

Quelldatensatz

uspto-grants-1998_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05776959