Bromine → N-(5-(2-bromoacetyl)-2-hydroxyphenyl)methanesulfonamide

HRID 1955786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1955786
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[NH:11][S:12]([CH3:15])(=[O:14])=[O:13].[Br:16]Br>O1CCOCC1>[Br:16][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[C:3]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:4]=1)=[O:10]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 19073226N-(5-acetyl-2-hydroxyphenyl)methanesulfonamide

Produkt 1

HCID 19073169N-(5-(2-bromoacetyl)-2-hydroxyphenyl)methanesulfonamideAusbeute 90,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a stirred 60° C. dioxane (35 mL) solution of 1-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethanone (2.06 g, 8.7 mmol) was rapidly added Br2 (1.48 g, 9.2 mmol). After one hour, the solution was cooled, concentrated and diluted with H2O. After filtration, the product was washed thoroughly with H2O, then with i-PrOH (9 mL), and air-dried to obtain the title compound (2.43 g, 84%).

Aufarbeitung

  1. customTo a stirred 60° C.
  2. temperaturethe solution was cooled
  3. concentrationconcentrated
  4. additiondiluted with H2O
  5. filtrationAfter filtration
  6. washthe product was washed thoroughly with H2O
  7. dry with materialwith i-PrOH (9 mL), and air-dried

Quellen und Nachweise

ORD-Eintrag
ord-b3ea20147bd9433e8acbac29c47f0f5f
Quelldatensatz
uspto-grants-1998_07
Patentnummer
US05776983

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