Acetamidine monohydrochloride → HCID 178499609, Verbindung

HRID 1957172Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1957172
[CH:1]([C:11]([O:13]C)=O)([C:7](OC)=[O:8])[CH2:2][C:3]([O:5][CH3:6])=[O:4].Cl.[C:16]([NH2:19])(=[NH:18])[CH3:17].C[O-].[Na+]>CO>[OH:13][C:11]1[C:1]([CH2:2][C:3]([O:5][CH3:6])=[O:4])=[C:7]([OH:8])[N:19]=[C:16]([CH3:17])[N:18]=1

Komponenten

5

Edukt 3

HCID 67170Acetamidine monohydrochlorideHCID 2911921,1,2-Trimethyl ethane-1,1,2-tricarboxylateHCID 10942334Sodium Methoxide

Produkt 1

HCID 178499609HCID 178499609, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Trimethyl ethane-1,1,2-tricarboxylate (204 g, 1 mol) and acetamidine hydrochloride (95 g, 1 mol) are added to a solution of sodium methylate (108 g, 2 mol) in methanol (600 ml) with stirring. The mixture is stirred for 16 hours at room temperature. Acidification with concentrated hydrochloric acid, filtration, washing with cold water and drying gives the methyl 4,6-dihydroxy-2-methyl-pyrimidin-5-yl-acetate (or tautomeric forms thereof) as a colorless solid (210 g), m.p.>200° C.

Aufarbeitung

  1. stirringThe mixture is stirred for 16 hours at room temperature
  2. filtrationAcidification with concentrated hydrochloric acid, filtration
  3. washwashing with cold water
  4. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-c566cc7fc5204cd3ab2a6b8bc5de8414
Quelldatensatz
uspto-grants-1998_07
Patentnummer
US05783580

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