Water → Methyl 8-methyl-5-nitrothieno[2,3-b]indole-2-carboxylate

HRID 1957215Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1957215
Cl[C:2]1[N:3]([CH3:16])[C:4]2[C:9]([C:10]=1[CH:11]=O)=[CH:8][C:7]([N+:13]([O-:15])=[O:14])=[CH:6][CH:5]=2.C([O-])([O-])=O.[K+].[K+].[SH:23][CH2:24][C:25]([O:27][CH3:28])=[O:26].O>CO>[CH3:16][N:3]1[C:4]2[C:9](=[CH:8][C:7]([N+:13]([O-:15])=[O:14])=[CH:6][CH:5]=2)[C:10]2[CH:11]=[C:24]([C:25]([O:27][CH3:28])=[O:26])[S:23][C:2]1=2

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 108238742-Chloro-1-methyl-5-nitroindole-3-carbaldehyde

Produkt 1

HCID 19068989Methyl 8-methyl-5-nitrothieno[2,3-b]indole-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1.4 g of (66) was added to a slurry of excess K2CO3 in 100 ml of MeOH. 2 ml of methyl 2-mercaptoacetate was added and the mixture left with stirring overnight. Addition of water precipitated the product, which was washed with MeOH and water to give 640 mg of (67). M. p. 269°-71° C.

Aufarbeitung

  1. waitthe mixture left
  2. customprecipitated the product, which
  3. washwas washed with MeOH and water

Quellen und Nachweise

ORD-Eintrag
ord-777f1d48539046ee8810b748702d8889
Quelldatensatz
uspto-grants-1998_07
Patentnummer
US05783575

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