Hydrochloric Acid → 1-(4,5-Dihydrothiazol-2-yl)azetidin-3-ol

To a solution of 109 mg of 3-hydroxyazetidine.HCl [Compound (1)] in 5 ml of ethanol was added a mixture of 133 mg of 2-methylthiazoline [Compound (2)] and sodium methoxide, and the reaction mixture was refluxed for 8 hours. After removal of the solvent under reduced pressure, the resulting residue was dissolved in chloroform and washed with 50% aqueous potassium carbonate solution. The solvent was removed under reduced pressure to give 119 mg (81.5%) of 3-hydroxy-1-(thiazolin-2-yl)azetidine [Compound (3)] as a crystaline.

1. temperaturethe reaction mixture was refluxed for 8 hours
2. customAfter removal of the solvent under reduced pressure
3. dissolutionthe resulting residue was dissolved in chloroform
4. washwashed with 50% aqueous potassium carbonate solution
5. customThe solvent was removed under reduced pressure

ORD-Eintrag

ord-df0909faa5fa4ec9a3fb619931707162

Quelldatensatz

uspto-grants-1998_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05783703