Potassium Carbonate → [(2-Chloro-5-nitro-pyrimidin-4-yl)-isopropyl-amino]-acetic acid ethyl ester

HRID 1957985

Reaktionsgleichung

Reaktionsgleichung von HRID 1957985
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[CH2:12]([O:14][C:15](=[O:21])[CH2:16][NH:17][CH:18]([CH3:20])[CH3:19])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.O>[CH2:12]([O:14][C:15](=[O:21])[CH2:16][N:17]([C:6]1[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=1)[CH:18]([CH3:20])[CH3:19])[CH3:13]

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 351625Ethyl 2-((propan-2-yl)amino)acetateHCID 5212662,4-Dichloro-5-nitropyrimidine

Produkt 1

HCID 59286164[(2-Chloro-5-nitro-pyrimidin-4-yl)-isopropyl-amino]-acetic acid ethyl esterAusbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

2,4-Dichloro-5-nitro-pyrimidine (40 g; 0.207 mol) was added to a cooled (0-10° C.) solution of isopropylamino-acetic acid ethyl ester (30 g; 0.207 mol) in 300 ml of acetone. A solution of potassium carbonate (28.5 g; 0.207 mol) in water was then added to the cooled reaction mixture. The reaction mixture was allowed to reach room temperature and was maintained at that temperature until complete conversion of the starting material into the desired product.

Aufarbeitung

  1. customto reach room temperature

Quellen und Nachweise

ORD-Eintrag
ord-412617fd421040c9b5955d19df5f669e
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410100B2

Verknüpfte Notizen

Wird geladen…