Methyl iodide → HCID 58405900, Verbindung

HRID 1957987

Reaktionsgleichung

Reaktionsgleichung von HRID 1957987
[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[CH2:6][N:5]([CH:13]([CH3:15])[CH3:14])[C:4]=2[N:3]=1.I[CH3:17].[H-].[Na+]>CC(N(C)C)=O>[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:17])[C:7](=[O:12])[CH2:6][N:5]([CH:13]([CH3:15])[CH3:14])[C:4]=2[N:3]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 592861702-chloro-8-isopropyl-7,8-dihydro-5H-pteridin-6-one

Produkt 1

HCID 58405900HCID 58405900, VerbindungAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

2-Chloro-8-isopropyl-7,8-dihydro-5H-pteridin-6-one (28 g; 0.118 mol) in Dimethylacetamide (100 ml) was cooled to −5° C. and iodomethane (8.839 ml; 0.141 mmol)) was quickly added. Then, NaH (7.1 g; 0.177 mmol) was added in portions. After 1 h the reaction mixture was allowed to reach room temperature and was maintained at that temperature until complete conversion of the starting material into the desired product. The reaction mixture was diluted with water and ice and the precipitate formed was filtered and dried in vacuo. 20 g (0.083 mol; 70% yield) of a white powder were obtained.

Aufarbeitung

  1. customto reach room temperature

Quellen und Nachweise

ORD-Eintrag
ord-861c82b804234e21adb9b8d7e298b6b1
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410100B2

Verknüpfte Notizen

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