Ethanol → 4-Amino-3-(benzylthio)-3-methylbutan-1-ol

HRID 1960256

Reaktionsgleichung

Reaktionsgleichung von HRID 1960256
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([S:14][C:15]([CH3:23])([CH2:19][N+:20]([O-])=O)[CH2:16][CH2:17][OH:18])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(O)C.O>O1CCCC1>[NH2:20][CH2:19][C:15]([S:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:23])[CH2:16][CH2:17][OH:18]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 574759763-(Benzylthio)-3-methyl-4-nitrobutan-1-ol

Produkt 1

HCID 574759774-Amino-3-(benzylthio)-3-methylbutan-1-olAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a mixture of lithium aluminum hydride (1.67 g) and tetrahydrofuran (30 ml) was added a solution of 3-(benzylthio)-3-methyl-4-nitrobutan-1-ol (3.00 g) in tetrahydrofuran (10 ml) over 1 hr at room temperature. The reaction mixture was stirred at room temperature for 1 hr, ethanol (10 ml) and water (6.4 ml) were added in this order, and the resulting inorganic salt was removed by filtration. The filtrate was concentrated, and the residue was dissolved in ethyl acetate, dried (MgSO4), and concentrated to give the title compound (2.62 g, yield 99%) as a yellow oil.

Aufarbeitung

  1. customthe resulting inorganic salt was removed by filtration
  2. concentrationThe filtrate was concentrated
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-e9bf906186a04b8d8b87ef23067b4ed6
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410087B2

Verknüpfte Notizen

Wird geladen…