HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Fluoro-3-(trifluoromethyl)benzonitrile → 4-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Fluoro-3-(trifluoromethyl)benzonitrile | HCID 144255 | — |
| Edukt | Sodium methanesulfinate | HCID 2733271 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 4-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile | HCID 45933716 | — |
Reaktionsbedingungen
| Temperatur | 80 °C |
|---|
Reaktionsschritte
4-Fluoro-3-(trifluoromethyl)benzonitrile (400 mg, 2.12 mmol) was suspended together with sodium methanesulfinate (216 mg, 2.12 mmol) in DMSO (2 ml) and stirred at 80° C. for 22 hours. The reaction was then cooled, diluted with 25 ml H2O and filtered. Filtered solids were evaporated from toluene to give 536 mg of the title substance (quant).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08415333B2 |
| Quelldatensatz | uspto-grants-2013_04 |
| ORD ID | ord-25131b47e8044a0abb5bb5e600f8a7d5 |
| Quellennotiz | uspto-grants-2013_04 |