Diisopropylethylamine → 4-(4-Iodobenzyl)thiomorpholine 1,1-dioxide

HRID 1961513Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1961513
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][CH:4]=1.[NH:10]1[CH2:15][CH2:14][S:13](=[O:17])(=[O:16])[CH2:12][CH2:11]1.CCN(C(C)C)C(C)C>C1COCC1>[I:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][N:10]2[CH2:15][CH2:14][S:13](=[O:17])(=[O:16])[CH2:12][CH2:11]2)=[CH:4][CH:5]=1

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 9542584-Iodobenzyl bromideHCID 6484228Thiomorpholine 1,1-dioxide

Produkt 1

HCID 582851564-(4-Iodobenzyl)thiomorpholine 1,1-dioxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1-(bromomethyl)-4-iodobenzene (1 g, 3.37 mmol), thiomorpholine 1,1-dioxide (0.546 g, 4.04 mmol) and DIPEA (0.882 mL, 5.05 mmol) were stirred in THF (15 mL) at room temperature overnight. The solvent was removed in vacuo while loading onto silica. Purification of the residue by MPLC (12-100% EtOAc-hexanes) gave 4-(4-iodobenzyl)thiomorpholine 1,1-dioxide as a white solid.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customPurification of the residue by MPLC (12-100% EtOAc-hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-905b96efb93c486e827d7e09bc522802
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415346B2

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