Reaktionsgleichung
C([O:3][C:4](=[O:19])[CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Br:18])C(OCC)=O)C.[OH-].[K+]>O>[Br:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][CH2:5][C:4]([OH:19])=[O:3]Komponenten
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
A 4-neck 2 litre round bottom flask with equipped with a reflux condenser, thermometer and stirrer, is charged with 230 g (0.70 mol) of 2-(2-Bromo-benzyl)-malonic acid diethyl ester and placed in an oil bath. A solution of 225.8 g (4.02 mol) potassium hydroxide in 225 ml water is slowly added with stirring. The reaction temperature is carefully monitored and the addition of the potassium hydroxide solution is interrupted as soon as a significantly exothermic reaction starts. The temperature may rise up to 80° C. The remaining potassium hydroxide solution is added as soon as the initial reaction starts to subside. It may happen that no change in temperature is observed while adding the potassium hydroxide solution. If this happens, the reaction mixture is carefully and slowly heated to 80° C. The exothermic reaction may suddenly start. As soon as the initial reaction starts to subside, the reaction mixture is heated to 100° C. and stirred for 6 h at this temperature.
Aufarbeitung
- customA 4-neck 2 litre round bottom flask with equipped with a reflux condenser
- customplaced in an oil bath
- customsoon as a significantly exothermic reaction
- custommay rise up to 80° C
- customreaction
- customThe exothermic reaction
- customAs soon as the initial reaction
- temperaturethe reaction mixture is heated to 100° C.
- stirringstirred for 6 h at this temperature
Quellen und Nachweise
- ORD-Eintrag
- ord-359e73b3e02149cd9be0f54c9a54e954
- Quelldatensatz
- uspto-grants-2013_04
- Patentnummer
- US08415492B2
Verknüpfte Notizen
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