3-Chloro-2,6-difluorobenzaldehyde → HCID 178517957, Verbindung

HRID 1967128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1967128
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[Cl:11][C:12]1[C:13]([F:21])=[C:14]([C:17]([F:20])=[CH:18][CH:19]=1)[CH:15]=O.[O:22]([C:24]#[N:25])[K].Cl.N1C=CC=CC=1.[N+:33]([CH:35]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH2:38][CH2:37][CH2:36]1)#[C-:34]>CO>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:15]([C:14]4[C:17]([F:20])=[CH:18][CH:19]=[C:12]([Cl:11])[C:13]=4[F:21])[C:34](=[N:33][CH:35]4[C:44]5[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=5)[CH2:38][CH2:37][CH2:36]4)[NH:25][C:24]3=[O:22])=[CH:9][C:4]=2[N:3]=[CH:2]1

Komponenten

7

Edukt 5

HCID 7363383-Chloro-2,6-difluorobenzaldehydeHCID 27594691,2,3,4-Tetrahydro-1-isocyanonaphthaleneHCID 10176127Pyridinium chlorideHCID 178418250HCID 178418250, VerbindungHCID 178507353HCID 178507353, Verbindung

Produkt 1

HCID 178517957HCID 178517957, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

1H-Benzoimidazol-5-ylamine (1 mmol) and 3-Chloro-2,6-difluorobenzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours 2 ml of a solution of KOCN (KSCN) (2 mmol) and Pyridinehydrochloride (2 mmol) in MeOH is added was added. Finally 1-Isocyano-1,2,3,4-tetrahydro-naphthalene (1 mmol) is added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Aufarbeitung

  1. additionwas added
  2. customAfter evaporation of the solvent the residue
  3. customwas purified with chromatographic methods

Quellen und Nachweise

ORD-Eintrag
ord-f10f4d3cd89d4ed59e64d655e59fada0
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08420684B2

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