N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide → 2-(4-amino-1H-pyrazol-1-yl)-N,N-dimethylacetamide

HRID 1968526Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1968526
[CH3:1][N:2]([CH3:14])[C:3](=[O:13])[CH2:4][N:5]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[N:6]1>CO.[Pd]>[NH2:10][C:8]1[CH:7]=[N:6][N:5]([CH2:4][C:3]([N:2]([CH3:14])[CH3:1])=[O:13])[CH:9]=1

Komponenten

4

Edukt 1

HCID 60729245N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide

Produkt 1

HCID 282806662-(4-amino-1H-pyrazol-1-yl)-N,N-dimethylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide (870 mg, 4.39 mmol) in methanol (22 ml) was evacuated/purged with nitrogen and treated with Pd on carbon (87 mg, 0.082 mmol). The resulting black suspension was evacuated/purged with a hydrogen balloon and stirred under the hydrogen overnight when the mixture was filtered through celite with methanol washes. The filtrate was concentrated to give the product.

Aufarbeitung

  1. customThe resulting black suspension was evacuated/purged with a hydrogen balloon
  2. filtrationwas filtered through celite with methanol washes
  3. concentrationThe filtrate was concentrated
  4. customto give the product

Quellen und Nachweise

ORD-Eintrag
ord-040b4427d31d498e92aa03cda395dbae
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426408B2

Notizen zur Reaktion

Wird geladen…