Hydrochloric Acid → 2-Nitro-5-phenoxybenzaldehyde

HRID 1968773

Reaktionsgleichung

Reaktionsgleichung von HRID 1968773
C[O:2][CH:3](OC)[C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[N+:17]([O-:19])=[O:18].Cl.O>C1COCC1>[N+:17]([C:5]1[CH:6]=[CH:7][C:8]([O:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:9][C:4]=1[CH:3]=[O:2])([O-:19])=[O:18]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 962Water2×HCID 34804522-(Dimethoxymethyl)-1-nitro-4-phenoxybenzene

Produkt 1

HCID 442030822-Nitro-5-phenoxybenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-(dimethoxymethyl)-1-nitro-4-phenoxy-benzene (7.4 g, 0.0256 mol) in THF (80 mL) was added 12 N HCl (10 mL) and water (20 mL). The resulting mixture was stirred at room temperature for 2 days. Water was then added, and the mixture was extracted with diisopropyl ether. The organic layer was separated, washed with 10% aqueous NaHCO3 solution and then with water, dried (MgSO4), filtered, and concentrated to yield a yellow solid.

Aufarbeitung

  1. extractionthe mixture was extracted with diisopropyl ether
  2. customThe organic layer was separated
  3. washwashed with 10% aqueous NaHCO3 solution
  4. dry with materialwith water, dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto yield a yellow solid

Quellen und Nachweise

ORD-Eintrag
ord-6f0a927456d549b8915e35b82fbfb6da
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426429B2

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