3-Benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester → Butyl 3-aminopyrrolidine-1-carboxylate

HRID 1970473Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1970473
[CH2:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([NH:13]C(OCC2C=CC=CC=2)=O)[CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Komponenten

4

Edukt 1

HCID 668545503-Benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester

Produkt 1

HCID 11608053Butyl 3-aminopyrrolidine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 467 mg 3-benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid butyl ester in 10 ml ethyl acetate was stirred in the presence of 50 mg Pd/C (10%) under an atmosphere of hydrogen (1 bar) for 12 h. The reaction mixture was filtrated, washed with ethyl acetate and concentrated to give the title compound as colorless oil.

Aufarbeitung

  1. filtrationThe reaction mixture was filtrated
  2. washwashed with ethyl acetate
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-5f9f7a17b08d4ee288852c9c73d4bca8
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426420B2

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