3-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester → Pyrrolidin-3-yl-carbamic acid butyl ester

HRID 1970478Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1970478
C(OC([N:11]1[CH2:15][CH2:14][CH:13]([NH:16][C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18])[CH2:12]1)=O)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[CH2:20]([O:19][C:17](=[O:18])[NH:16][CH:13]1[CH2:14][CH2:15][NH:11][CH2:12]1)[CH2:21][CH2:22][CH3:23]

Komponenten

4

Edukt 1

HCID 668544263-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester

Produkt 1

HCID 20242877Pyrrolidin-3-yl-carbamic acid butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 467 mg 3-butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester in 10 ml ethyl acetate was stirred in the presence of 100 mg Pd/C (10%) under an atmosphere of hydrogen (1 bar) for 12 h. The reaction mixture was filtrated, washed with ethyl acetate and concentrated to give the title compound as colorless oil.

Aufarbeitung

  1. filtrationThe reaction mixture was filtrated
  2. washwashed with ethyl acetate
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-bea721c1ac824d4b9b92af0dde2109ba
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426420B2

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