1-Benzyl 4-ethyl (2R)-2-methylpiperazine-1,4-dicarboxylate → Ethyl (3R)-3-methylpiperazine-1-carboxylate

HRID 1970543Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1970543
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9](C(OCC2C=CC=CC=2)=O)[C@H:8]([CH3:22])[CH2:7]1)=[O:5])[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][C@H:8]([CH3:22])[CH2:7]1)=[O:5])[CH3:2]

Komponenten

4

Edukt 1

HCID 668549451-Benzyl 4-ethyl (2R)-2-methylpiperazine-1,4-dicarboxylate

Produkt 1

HCID 45099579Ethyl (3R)-3-methylpiperazine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A suspension of 3.0 g (R)-2-Methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester and 0.4 g Pd/C (10%) in 48 ml ethyl acetate was stirred under an atmosphere of hydrogen (3 bar) for 12 h. The mixture was filtrated over a plug of Celite, washed with ethyl acetate and the combined wash solutions concentrated to give the title compound as colourless oil. Yield: 1.5 g.

Aufarbeitung

  1. filtrationThe mixture was filtrated over a plug of Celite
  2. washwashed with ethyl acetate
  3. concentrationthe combined wash solutions concentrated

Quellen und Nachweise

ORD-Eintrag
ord-89caeaccb19b47a69283a07e46931ebe
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426420B2

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