Acetonitrile → 2,2-dimethyl-N,N-dipyridin-2-ylpropanamide

HRID 1970729

Reaktionsgleichung

Reaktionsgleichung von HRID 1970729
[CH:1]1[CH:6]=[C:5]([NH:7][C:8]2[N:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:4]=[CH:3][CH:2]=1.C(#N)C.C(N(CC)CC)C.[CH3:24][C:25]([CH3:30])([CH3:29])[C:26](Cl)=[O:27]>O>[CH3:24][C:25]([CH3:30])([CH3:29])[C:26]([N:7]([C:5]1[CH:6]=[CH:1][CH:2]=[CH:3][N:4]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][N:13]=1)=[O:27]

Komponenten

6

Edukt 4

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 145472,2'-DipyridylamineHCID 62493Pivaloyl chloride

Produkt 1

HCID 666280902,2-dimethyl-N,N-dipyridin-2-ylpropanamideAusbeute 60,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a flask were added 2.0 g of 2,2′-dipyridylamine and 35 ml of acetonitrile. The solution was stirred under nitrogen and cooled to 5 C, when 1.5 g of triethylamine were added, followed by 1.5 g of trimethylacetyl chloride and the mixture was allowed to warm to 22 C. After 1 hour, 50 ml of water were added and the acetonitrile was removed. The product was extracted with ethyl acetate and washed with water. Following solvent removal, the product was purified by silica gel chromatography using 50% ethyl acetate in hexane, resulting in 1.8 g of an oil that solidified on standing.

Aufarbeitung

  1. additionwere added
  2. temperatureto warm to 22 C
  3. customthe acetonitrile was removed
  4. extractionThe product was extracted with ethyl acetate
  5. washwashed with water
  6. customFollowing solvent removal
  7. customthe product was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-d24177128375469396d7d381410d0ef8
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08431045B2

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