HCID 59543137, Verbindung → 4-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanamine

HRID 1970989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1970989
[N:1]([CH:4]1[CH2:9][CH2:8][CH:7]([O:10][Si:11]([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12])[CH:6]([F:18])[CH2:5]1)=[N+]=[N-]>CO.[Pd]>[Si:11]([O:10][CH:7]1[CH2:8][CH2:9][CH:4]([NH2:1])[CH2:5][CH:6]1[F:18])([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12]

Komponenten

4

Edukt 1

HCID 59543137HCID 59543137, Verbindung

Produkt 1

HCID 595431224-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a stirred solution [(4-azido-2-fluorocyclohexyl)oxy](tert-butyl)dimethylsilane (1.0 g, 3.66 mmol) in MeOH (15 mL) was added Pd/C in MeOH. The flask was evacuated and filled with hydrogen several times, and left to stir overnight under hydrogen atmosphere. The mixture was diluted with DCM, filtered through a pad of Celite, and concentrated to afford the title compound.

Aufarbeitung

  1. customThe flask was evacuated
  2. additionfilled with hydrogen several times
  3. waitleft
  4. additionThe mixture was diluted with DCM
  5. filtrationfiltered through a pad of Celite
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-8bae95b7b94349f9b70c918431b8eece
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08431569B2

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