Diethyl Ether → HCID 178496014, Verbindung

HRID 1971140Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1971140
[NH2:1][C:2]([NH:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH3:24])[CH:22]=2)[N:17]=[C:16]([C:25]([NH:27][CH2:28][CH2:29][O:30][CH3:31])=[O:26])[N:15]=1)=[N:3][O:4][CH3:5].C(OCC)(=O)C.[ClH:38].C(OCC)C>C(OCC)(=O)C>[ClH:38].[ClH:38].[NH2:1][C:2]([NH:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH3:24])[CH:22]=2)[N:17]=[C:16]([C:25]([NH:27][CH2:28][CH2:29][O:30][CH3:31])=[O:26])[N:15]=1)=[N:3][O:4][CH3:5]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 21866389Hydrogen chloride-ethyl acetateHCID 178496013HCID 178496013, Verbindung

Produkt 1

HCID 178496014HCID 178496014, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1.71 g of 4-[((1S,2R)-2-{[amino(methoxyimino) methyl]amino}cyclohexyl)amino]-N-(2-methoxyethyl)-6-methyl quinazolin-2-carboxamide was suspended in 20 ml of ethyl acetate, and 5 ml of a 4 N hydrogen chloride-ethyl acetate solution was added thereto, and the mixture was stirred for 15 minutes. To the reaction solution, 40 ml of diethyl ether was added, and the resulting deposited substance was collected by filtration, washed with diethyl ether and dried under reduced pressure, whereby 2.01 g of a desired compound was obtained as a white powder.

Aufarbeitung

  1. filtrationwas collected by filtration
  2. washwashed with diethyl ether
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-02b16f873d09457092b3354807b28779
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08431586B2

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