Water → 2-Bromo-2-phenylacetamide

HRID 1971618

Reaktionsgleichung

Reaktionsgleichung von HRID 1971618
[C:1]1([CH2:7][C:8]([NH2:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:11]N1C(=O)CCC1=O.O>ClCCl>[Br:11][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:8]([NH2:10])=[O:9]

Komponenten

5

Edukt 3

HCID 962WaterHCID 7680BenzeneacetamideHCID 67184N-bromobutanimide

Produkt 1

HCID 2420282-Bromo-2-phenylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Benzeneacetamide (3.0 g, 0.022 mol) was dissolved in dichloromethane (60 mL) and N-bromosuccinimide (4.0 g, 0.022 mol) was added. The reaction was stirred at room temperature under UV light for 24 hr. The mixture was poured into water and the layers were separated. The organic layer was washed with water (2×50 mL) then with brine (1×50 mL). The organic layer was dried (magnesium sulfate) then chromatographed on silica (40% ethyl acetate/hexanes) to give 2-Bromo-2-phenylacetamide, compound h Rf 0.37, 40% ethyl acetate/hexanes; MS m/z 216 (M+H).

Aufarbeitung

  1. customthe layers were separated
  2. washThe organic layer was washed with water (2×50 mL)
  3. dry with materialThe organic layer was dried (magnesium sulfate)
  4. customthen chromatographed on silica (40% ethyl acetate/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-bd79f96846d84017b4148134f41aa0d1
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08431608B2

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