HCID 86657843, Verbindung → tert-butyl 3-amino-4,4-difluoropiperidine-1-carboxylate

HRID 1972096Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1972096
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([F:15])([F:14])[CH:10]([N:16]=[N+]=[N-])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([F:14])([F:15])[CH:10]([NH2:16])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 1

HCID 86657843HCID 86657843, Verbindung

Produkt 1

HCID 67373260tert-butyl 3-amino-4,4-difluoropiperidine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 3-azido-4,4-difluoro-piperidine-1-carboxylic acid tert-butyl ester (0.68 mmol, 0.18 g) in MeOH (4.0 mL), was added Pd—C (10% by wt, 30 mg) and stirred under H2 atmosphere (balloon) for 3 h. The catalyst was filtered and washed with DCM, and the filtrate was concentrated under reduced pressure to provide 3-amino-4,4-difluoro-piperidine-1-carboxylic acid tert-butyl ester.

Aufarbeitung

  1. filtrationThe catalyst was filtered
  2. washwashed with DCM
  3. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2e64d8a7cc864c8aa27baf6e4e60441b
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08431575B2

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