Trifluoroacetic acid → 2-(3-(4-(4-Chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethyl carbamate

HRID 1972226Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1972226
[Cl:1][C:2]1[CH:33]=[CH:32][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=4)[CH2:16][N:15]([CH2:28][CH2:29][OH:30])[C:14]3=[O:31])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[O-:34][C:35]#[N:36].[Na+].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:35](=[O:34])([O:30][CH2:29][CH2:28][N:15]1[CH2:16][CH:17]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=2)[N:13]([C:10]2[CH:9]=[CH:8][C:7]([O:6][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:33][CH:32]=3)=[CH:12][CH:11]=2)[C:14]1=[O:31])[NH2:36]

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 517096Sodium CyanateHCID 59485645HCID 59485645, Verbindung

Produkt 1

HCID 594860492-(3-(4-(4-Chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethyl carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 3-(4-(4-chlorophenoxy)phenyl)-1-(2-hydroxyethyl)-4-(3-(trifluoromethyl)phenyl)imidazolidin-2-one (10.0 mg, 0.021 mmol) in DCM (0.3 mL) are added sodium cyanate (5.5 mg, 0.084 mmol) and TFA (6.46 μL, 0.084 mmol). The mixture is stirred at room temperature overnight before removal of the solvent. The residue is purified by preparatory TLC to provide the title compound; HPLC-MS calculated for C25H21ClF3N3O4 (M+H+) 520.1, found 520.1.

Aufarbeitung

  1. customThe residue is purified by preparatory TLC

Quellen und Nachweise

ORD-Eintrag
ord-629f58566e7c47bbb26b98647f717eb8
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08431607B2

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