Potassium Hydroxide → 2-(2,2,2-Trifluoroethoxy)benzoic acid
Reaktionsgleichung
[F:1][C:2]([F:16])([F:15])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8].[OH-].[K+]>O>[F:1][C:2]([F:15])([F:16])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Methyl 2-(2,2,2-trifluoroethoxy)benzoate (8 g., 34.2 mmoles) potassium hydroxide (3.3 g., 350 mmoles), water (50 ml.) and alcohol (25 ml.) are heated together under reflux for 1.5 hours, and distilled until ca. 25 ml. of distillate is removed. The cooled residue is acidified (pH 3) and the resulting white solid is collected and recrystallized (aqueous alcohol) to give fluffy white solid, m.p. 85°-86.5° C.
Aufarbeitung
- temperatureunder reflux for 1.5 hours
- distillationdistilled until ca. 25 ml
- customof distillate is removed
- customthe resulting white solid is collected
- customrecrystallized (aqueous alcohol)
- customto give fluffy white solid, m.p. 85°-86.5° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-7a78e4d087714dbd9e54ca28584bf433
- Quelldatensatz
- uspto-grants-1976_12
- Patentnummer
- US03996280
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