Potassium → N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-acenaphthene-1,2-dicarboximide

HRID 1973448

Reaktionsgleichung

Reaktionsgleichung von HRID 1973448
[CH:1]12[C:15](=[O:16])[NH:14][C:13](=[O:17])[CH:2]1[C:3]1[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]2=3)[CH:6]=[CH:5][CH:4]=1.[K].S(C1C=CC(C)=CC=1)(O)(=O)=O.O[CH2:31][CH2:32][N:33]1[C:37]([N+:38]([O-:40])=[O:39])=[CH:36][N:35]=[C:34]1[CH3:41]>O>[CH3:41][C:34]1[N:33]([CH2:32][CH2:31][N:14]2[C:13](=[O:17])[CH:2]3[C:3]4[C:12]5[C:7](=[CH:8][CH:9]=[CH:10][C:11]=5[CH:1]3[C:15]2=[O:16])[CH:6]=[CH:5][CH:4]=4)[C:37]([N+:38]([O-:40])=[O:39])=[CH:36][N:35]=1

Komponenten

5

Edukt 3

HCID 5462222PotassiumHCID 21491653Acenaphthene-1,2-dicarboximideHCID 867342581-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole tosylate

Produkt 1

HCID 21491671N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-acenaphthene-1,2-dicarboximide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Acenaphthene-1,2-dicarboximide is converted to the potassium salt and reacted with 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole tosylate according to the procedure described in Example 13. The crude reaction mixture is cooled and diluted with water, and then extracted with toluene. The solvent is evaporated from the toluene extract and the residue recrystallized from ethanol to give N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-acenaphthene-1,2-dicarboximide melting at about 183°-185° C.

Aufarbeitung

  1. customThe crude reaction mixture
  2. temperatureis cooled
  3. extractionextracted with toluene
  4. customThe solvent is evaporated from the toluene
  5. extractionextract
  6. customthe residue recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-89f21b68d4a7411f94b4a050c9f0a229
Quelldatensatz
uspto-grants-1976_12
Patentnummer
US03997572

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