Diazoethane → Ethyl 6-methoxymethyloxy-2-naphthyl-alpha-methylacetate

HRID 1973993Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1973993
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([CH:15]([CH3:19])[C:16]([OH:18])=[O:17])[CH:9]=[CH:8]2.[N+](=[CH:22][CH3:23])=[N-]>C(OCC)C>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([CH:15]([CH3:19])[C:16]([O:18][CH2:22][CH3:23])=[O:17])[CH:9]=[CH:8]2

Komponenten

4

Edukt 2

HCID 70695DiazoethaneHCID 203350726-Methoxymethyloxy-2-naphthyl-alpha-methylacetic acid

Produkt 1

HCID 70589918Ethyl 6-methoxymethyloxy-2-naphthyl-alpha-methylacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a solution of 26 g. of 6-methoxymethyloxy-2-naphthyl-α-methylacetic acid and 500 ml. of diethyl ether are slowly added a solution comprising of 5.6 g. of diazoethane and 50 ml. of diethyl ether. The reaction mixture is allowed to stand for 15 minutes and then is evaporated under reduced pressure to yield ethyl 6-methoxymethyloxy-2-naphthyl-α-methylacetate. By replacing diazoethane with diazopropane in the above process, propyl 6-methoxymethyloxy-2-naphthyl-α-methylacetate is obtained.

Aufarbeitung

  1. customis evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fffc5430bd27417d9921567284ad1e0e
Quelldatensatz
uspto-grants-1976_12
Patentnummer
US03998966

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