Sulfuric Acid → 2-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)benzamide

HRID 1974326Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1974326
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[N:11]=[N:10]1)#[N:2].S(=O)(=O)(O)[OH:19].[OH-].[NH4+]>>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[N:11]=[N:10]1)(=[O:19])[NH2:2]

Komponenten

4

Edukt 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 124454992-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)benzonitrile

Produkt 1

HCID 124455002-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)benzamide

Versuchsvorschrift

The cyano compound (from Example 7) (600 mg.) was dissolved in 8 ml. of concentrated sulfuric acid with ice cooling. After standing at room temperature for 7 hours it was poured onto ice. The cold solution was treated with an excess of ammonium hydroxide. The precipitate was collected, air dried and recrystallized from dimethylformamide and water to give 3-(2-carbamoylphenyl)-3H-1,2,3-triazolo[4,5-b]pyridine, m.p. >340° C.

Aufarbeitung

  1. additionit was poured onto ice
  2. customThe precipitate was collected
  3. customair dried
  4. customrecrystallized from dimethylformamide and water

Quellen und Nachweise

ORD-Eintrag
ord-9bf51204d5484c06a9628526e635a6d7
Quelldatensatz
uspto-grants-1976_12
Patentnummer
US04000286

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