Hydrazine hydrate (1:1) → 4-Hydrazino-2-(trifluoromethyl)quinazoline

HRID 1974817

Reaktionsgleichung

Reaktionsgleichung von HRID 1974817
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1.O.[NH2:17][NH2:18]>C(O)C>[NH:17]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1)[NH2:18]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 14754354-chloro-2-(trifluoromethyl)quinazoline

Produkt 1

HCID 14754644-Hydrazino-2-(trifluoromethyl)quinazoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4-Chloro-2-trifluoromethylquinazoline (46.4 g, 0.2 mole) was taken up in ethanol (500 ml). Hydrazine hydrate (20 ml, 0.4 mole) was added and the contents refluxed for 2 hours. On cooling, the yellow precipitate was filtered and slurried in water (500 ml) to removed hydrazine hydrochloride. Filtration gave the product as a yellow crystalline solid, 34.5 g (76%).

Aufarbeitung

  1. temperaturethe contents refluxed for 2 hours
  2. temperatureOn cooling
  3. filtrationthe yellow precipitate was filtered
  4. customto removed hydrazine hydrochloride
  5. filtrationFiltration

Quellen und Nachweise

ORD-Eintrag
ord-660c1964dfcd4fa88cf7408a28da8c43
Quelldatensatz
uspto-grants-1994_02
Patentnummer
US05284739

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