Sodium Hydroxide → 2-Methoxypyridin-4-amine

HRID 1974832

Reaktionsgleichung

Reaktionsgleichung von HRID 1974832
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][N+:4]=1[O-].[OH-].[Na+]>C(O)(=O)C.[Fe]>[NH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 5792072-Methoxy-4-nitropyridine-n-oxide

Produkt 1

HCID 2808912-Methoxypyridin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 6.3 g of 2-methoxy-4-nitropyridine N-oxide and 12.6 g of iron powder in 150 ml of acetic acid is heated for 1 hour at 100° C. After cooling, sodium hydroxide is added, the mixture is then filtered and the material on the filter is washed with water. The aqueous phase is extracted with ethyl ether. After drying and concentration, 3.6 g of an oil are recovered which crystallizes to a white solid.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe mixture is then filtered
  3. washthe material on the filter is washed with water
  4. extractionThe aqueous phase is extracted with ethyl ether
  5. customAfter drying
  6. concentrationconcentration, 3.6 g of an oil
  7. customare recovered which
  8. customcrystallizes to a white solid

Quellen und Nachweise

ORD-Eintrag
ord-90187e1883424e1999df727823c3ea76
Quelldatensatz
uspto-grants-1994_02
Patentnummer
US05284838

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