1-Benzyl-5-methyloctahydropyrrolo[3,4-b]pyrrole → 5-Methyl-octahydropyrrolo(3,4-b)pyrrole
Reaktionsgleichung
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([CH3:16])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][N:11]1[CH2:10][CH:9]2[CH:13]([CH2:14][CH2:15][NH:8]2)[CH2:12]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
10.3 g (47.6 mmol) of 2-benzyl-7-methyl-2,7-diazabicyclo(3.3.0]octane in 200 ml of ethanol are hydrogenated on 2.5 g of palladium/active carbon (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated, and the residue is distilled.
Aufarbeitung
- filtrationThe catalyst is filtered off with suction
- concentrationthe filtrate is concentrated
- distillationthe residue is distilled
Quellen und Nachweise
- ORD-Eintrag
- ord-5f5dbde6bc2445e8ba8c306010fc8159
- Quelldatensatz
- uspto-grants-1994_02
- Patentnummer
- US05284855
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