Acetic Anhydride → N-(hydroxymethyl)acetamide acetate

HRID 1975195Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1975195
[C:1]([O:4]C(=O)C)(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]>N1C=CC=CC=1>[C:1]([OH:4])(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 69365Formicin

Produkt 1

HCID 86745977N-(hydroxymethyl)acetamide acetateAusbeute 900 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineKatalysator

Versuchsvorschrift

Acetic anhydride (25 g) and pyridine (10 drops) is added to N-(hydroxymethyl)acetamide (9 g, 0.1 mol). The reaction mixture is stirred overnight at room temperature, concentrated in vacuo and chased with xylene to give the title product as an oil (11.9 g, 0.9 mol) which is identified by 1HNMR spectral analysis.

Aufarbeitung

  1. concentrationconcentrated in vacuo and chased with xylene

Quellen und Nachweise

ORD-Eintrag
ord-7535a1d5963243b8873229521813e4f6
Quelldatensatz
uspto-grants-1994_02
Patentnummer
US05284863

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