Hydrazine hydrate (1:1) → [4'-Fluoro-2-(4-trifluoromethylphenyl)acetophenone]hydrazone

HRID 1975657

Reaktionsgleichung

Reaktionsgleichung von HRID 1975657
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.O.[NH2:22][NH2:23]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:22][NH2:23])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 98172164'-Fluoro-2-(4-trifluoromethylphenyl)acetophenone

Produkt 1

HCID 85677185[4'-Fluoro-2-(4-trifluoromethylphenyl)acetophenone]hydrazone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

5.1 g (18.1 mmol) of 4'-fluoro-2-(4-trifluoromethylphenyl)acetophenone was dissolved in 100 ml of ethanol, and 8.8 ml (181 mmol) of hydrazine monohydrate was added thereto. The mixture was refluxed under heating for 2 hours. After completion of the reaction, ethanol was distilled off under reduced pressure, and water was added to the residue. The mixture was extracted with dichloromethane. The extract was dried over an hydrous sodium sulfate, and the solvent was distilled off to obtain [4'-fluoro-2-(4-trifluoromethylphenyl)acetophenone]hydrazone as a yellow oily substance.

Aufarbeitung

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating for 2 hours
  3. distillationwas distilled off under reduced pressure, and water
  4. additionwas added to the residue
  5. extractionThe mixture was extracted with dichloromethane
  6. dry with materialThe extract was dried over an hydrous sodium sulfate
  7. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-5ddb47e1406345ea80569a0f87ba740d
Quelldatensatz
uspto-grants-1994_02
Patentnummer
US05288727

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