Water → 1,2,3,6-Tetrahydro-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-pyridinol

HRID 1976270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1976270
Br.Br[CH:3]1[C:8]([C:9]2[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=2[O:19][CH3:20])=[CH:7][CH2:6][N:5]([CH3:21])[CH2:4]1.[OH2:22]>>[OH:22][CH:3]1[C:8]([C:9]2[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=2[O:19][CH3:20])=[CH:7][CH2:6][N:5]([CH3:21])[CH2:4]1

Komponenten

3

Edukt 2

HCID 962WaterHCID 9866952HCID 9866952, Verbindung

Produkt 1

HCID 99256571,2,3,6-Tetrahydro-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-pyridinol

Versuchsvorschrift

treating the reaction mixture containing the compound (VI) directly with water and reacting by stirring at 50°-100° C., preferably at 60°-80° C., to give 3(R,S)-hydroxy-1-methyl4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydropyridine (VII), and

Aufarbeitung

  1. additiontreating the reaction mixture

Quellen und Nachweise

ORD-Eintrag
ord-f260aa7d90794869aa5c027989fdd3f5
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06225473B1

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