Acetonitrile → HCID 21995116, Verbindung
Reaktionsgleichung
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([C:10]1[N:14]([CH3:15])[N:13]=[C:12]([CH2:16][CH2:17][CH3:18])[C:11]=1[NH:19][C:20](=[O:30])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26](Br)=[CH:25]C=1)(=[O:9])[NH2:8].[C:31](#N)C>>[C:7]([C:10]1[N:14]([CH3:15])[N:13]=[C:12]([CH2:16][CH2:17][CH3:18])[C:11]=1[NH:19][C:20](=[O:30])[CH2:21][C:22]1[CH:23]=[CH:28][C:27]([CH2:31][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:26][CH:25]=1)(=[O:9])[NH2:8]Komponenten
4
Versuchsvorschrift
Morpholine (0.3 ml, 0.00344 mol) was added to a solution of N-(5-carbamoyl-1-methyl-3-propyl-1H-4-pyrazolyl)-2-(4-bromobenzyl)acetamide (400 mg, 0.001 mol) in acetonitrile (3 ml) and the reaction stirred at reflux for 2 hours. On cooling, the reaction was concentrated under reduced pressure.
Aufarbeitung
- temperatureat reflux for 2 hours
- temperatureOn cooling
- concentration