Ethyl cyanoacetate → Ethyl 2-cyano-3-hydroxy-4,4,5,5,5-pentafluoro-2-pentenoate

HRID 1978168

Reaktionsgleichung

Reaktionsgleichung von HRID 1978168
[C:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].C(N(CC)CC)C.[F:16][C:17]([F:25])([C:21]([F:24])([F:23])[F:22])[C:18](Cl)=[O:19]>O1CCCC1>[C:1]([C:3](=[C:18]([OH:19])[C:17]([F:25])([F:16])[C:21]([F:24])([F:23])[F:22])[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2]

Komponenten

5

Edukt 3

HCID 7764Ethyl cyanoacetateHCID 8471TriethylamineHCID 67911Perfluoropropionyl chloride

Produkt 1

HCID 86756713Ethyl 2-cyano-3-hydroxy-4,4,5,5,5-pentafluoro-2-pentenoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To 20 ml of tetrahydrofuran, 3.39 g (30 mmol) of ethyl cyanoacetate and 6.06 g (60 mmol) of triethylamine were dissolved and stirred at room temperature. Successively, 5.47 g (30 mmol) of pentafluoropropionyl chloride was dropwise added and stirred for 5 hours at room temperature. However, formation of desired product could not be confirmed.

Aufarbeitung

  1. stirringstirred for 5 hours at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-5ebf959e1e1d4832bd243770b69d9c26
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06235911B1

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