Sodium Iodide → HCID 21995730, Verbindung

HRID 1978740

Reaktionsgleichung

Reaktionsgleichung von HRID 1978740
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([O:9][CH2:10][CH3:11])[CH:3]=1.Br[CH2:13][CH2:14][CH3:15].[I-].[Na+].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:13][CH2:14][CH3:15])=[C:4]([O:9][CH2:10][CH3:11])[CH:3]=1

Komponenten

6

Edukt 4

HCID 5238Sodium IodideHCID 78401-BromopropaneHCID 11430Potassium CarbonateHCID 218775414-Bromo-2-ethoxyphenol

Produkt 1

HCID 21995730HCID 21995730, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

A suspension of 4-bromo-2-ethoxyphenol (8 g), 1-bromopropane (4 ml), sodium iodide (5.5 g) and potassium carbonate (10.2 g) in DMF (10 ml) was stirred under nitrogen atmosphere at 75° C. overnight. The solvent was evaporated, and to the residue was added water. The mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine and dried with anhydrous magnesium sulfate. The solvent was evaporated, and the residue was distilled under reduced pressure to give 1-bromo-3-ethoxy-4-propoxybenzene (8.5 g) as pale yellow oil.

Aufarbeitung

  1. customThe solvent was evaporated
  2. additionto the residue was added water
  3. extractionThe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with water and saturated brine
  5. dry with materialdried with anhydrous magnesium sulfate
  6. customThe solvent was evaporated
  7. distillationthe residue was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-89e7e347ff354fe6a9f5d3a6785fac18
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06235771B1

Verknüpfte Notizen

Wird geladen…