Sodium Carbonate → 4-Hydroxyimino-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid

HRID 1979169Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1979169
O=[C:2]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].Cl.[NH2:25][OH:26].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[OH:26][N:25]=[C:2]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 230052404-Oxo-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid

Produkt 1

HCID 865835174-Hydroxyimino-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acidAusbeute 60,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In a manner similar to Example 4, Step (c), 4-oxo-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid (1.20 g, 0.00372 mol) was allowed to react with hydroxylamine hydrochloride (0.3115 g, 0.00448 mol) in the presence of sodium carbonate (0.4768 g, 0.00450 mol) in absolute ethanol (20 mL) to give 0.764 g of 4-hydroxyimino-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid as a white solid; mp 134-136° C.

Quellen und Nachweise

ORD-Eintrag
ord-1439746aa14d470bb97911d99d302c57
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06239288B1

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