Sodium Carbonate → 4-(4'-Tert-butyl-biphenyl-4-yl)-4-hydroxyimino-butyric acid

HRID 1979175Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1979175
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17](=O)[CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:25][OH:26].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17](=[N:25][OH:26])[CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 183641354-(4'-Tert-butyl-biphenyl-4-yl)-4-oxo-butyric acid

Produkt 1

HCID 734323234-(4'-Tert-butyl-biphenyl-4-yl)-4-hydroxyimino-butyric acidAusbeute 93,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In a manner similar to Example 4, Step (c), 4-(4′-tert-butyl-biphenyl-4-yl)-4-oxo-butyric acid (0.277 g, 0.000892 mol) was allowed to react with hydroxylamine hydrochloride (0.0704 g, 0.00101 mol) in the presence of sodium carbonate (0.1074 g, 0.00101 mol) in absolute ethanol (7 mL) to give 0.272 g of 4-(4′-tert-butyl-biphenyl-4-yl)-4-hydroxyimino-butyric acid as a white solid; mp 170.5-171.5° C.

Quellen und Nachweise

ORD-Eintrag
ord-a0be54f35e9148778ae2dc1f245b4f56
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06239288B1

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