Methanethiol → N-(2-Hydroxyethyl)-N-methylguanidine sulfate (2:1)

HRID 1981153Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1981153
[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[CH3:6][NH:7][C:8](=[NH:10])S.OCC[NH:14]C.CS.[CH:18]([OH:21])(C)[CH3:19]>C(O)C>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[OH:21][CH2:18][CH2:19][N:7]([CH3:6])[C:8]([NH2:10])=[NH:14]

Komponenten

6

Edukt 4

HCID 878MethanethiolHCID 3776IsopropanolHCID 80162-(Methylamino)ethanolHCID 178485225HCID 178485225, Verbindung

Produkt 1

HCID 20399896N-(2-Hydroxyethyl)-N-methylguanidine sulfate (2:1)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The above intermediate N-(2-hydroxyethyl)-N-methylquanidine sulfate was prepared as follows: A mixture containing 83.6 g of methyl isothiourea sulfate and 90 g of N-(2-hydroxyethyl)methylamine was heated on a steam bath under vacuum until no more methyl mercaptan was evolved. The solid remaining was boiled successively with hot isopropyl alcohol, hot absolute ethanol and then ether, and collected to yield 91 g of crystalline N-(2-hydroxyethyl)-N-methylguanidine sulfate.

Aufarbeitung

  1. customether, and collected

Quellen und Nachweise

ORD-Eintrag
ord-f46e361758fc4810b257df44f7b9c0a6
Quelldatensatz
uspto-grants-1985_04
Patentnummer
US04512993

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