3-Trifluoromethyl-4'-benzyloxy-alpha-ethyl-benzhydrol → 3-Trifluoromethyl-4'-hydroxy-alpha-ethylbenzhydrol

HRID 1981558

Reaktionsgleichung

Reaktionsgleichung von HRID 1981558
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[C:6]([CH2:22][CH3:23])([OH:21])[C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1.[H][H]>[Pd].CO>[F:1][C:2]([F:27])([F:28])[C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[C:6]([CH2:22][CH3:23])([OH:21])[C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1

Komponenten

5

Edukt 2

HCID 202398663-Trifluoromethyl-4'-benzyloxy-alpha-ethyl-benzhydrolHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 1818763-Trifluoromethyl-4'-hydroxy-alpha-ethylbenzhydrol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

54.1 g. of 3-trifluoromethyl-4'-benzyloxy-α-ethyl-benzhydrol in 541 ml. of methanol are hydrogenated under atmospheric pressure, in the presence of 27.1 g. of a 10% palladium-on-charcoal catalyst. When the uptake of the calculated amount of hydrogen is complete, the catalyst is filtered off, and the solvent is distilled off under reduced pressure. The crude product is decoloured with charcoal in ethyl acetate, and recrystallized from a mixture of ethyl acetate and n-hexane. 30.8 g. of the named compound are obtained, melting at 102.5° to 103° C.

Aufarbeitung

  1. filtrationthe catalyst is filtered off
  2. distillationthe solvent is distilled off under reduced pressure
  3. customrecrystallized from a mixture of ethyl acetate and n-hexane
  4. customof the named compound are obtained

Quellen und Nachweise

ORD-Eintrag
ord-7fc03fb4c9b04d1a902be11de0f1e52a
Quelldatensatz
uspto-grants-1986_06
Patentnummer
US04593047

Verknüpfte Notizen

Wird geladen…