Dimethylamine → 4-Cyclohexyl-2-[(dimethylamino)methyl]-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5(4H)-one oxalate

HRID 1981748

Reaktionsgleichung

Reaktionsgleichung von HRID 1981748
Cl[CH2:2][CH:3]1[CH2:9][N:8]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[C:7](=[O:16])[C:6]2[CH:17]=[CH:18][CH:19]=[N:20][C:5]=2[O:4]1.[CH3:21][NH:22][CH3:23].[C:24]([OH:29])(=[O:28])[C:25]([OH:27])=[O:26]>C(O)(C)C>[C:24]([OH:29])(=[O:28])[C:25]([OH:27])=[O:26].[CH:10]1([N:8]2[C:7](=[O:16])[C:6]3[CH:17]=[CH:18][CH:19]=[N:20][C:5]=3[O:4][CH:3]([CH2:2][N:22]([CH3:23])[CH3:21])[CH2:9]2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Komponenten

5

Edukt 3

HCID 674DimethylamineHCID 971Oxalic AcidHCID 13729322chloromethyl-4-cyclohexyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5(4H)-one2×

Produkt 1

HCID 212714644-Cyclohexyl-2-[(dimethylamino)methyl]-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5(4H)-one oxalate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

Utilizing the procedure of Example 10, 2-(chloromethyl)-4-cyclohexyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5(4H)-one (Intermediate 35) is reacted with 40% aqueous dimethylamine and treated with oxalic acid in isopropyl alcohol.

Quellen und Nachweise

ORD-Eintrag
ord-a6e14d0f685144d9b9d6c769f1d5cf31
Quelldatensatz
uspto-grants-1986_06
Patentnummer
US04592866

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