Water → N-(2-Oxo-1-phenylpropyl)hexanamide

HRID 1982436Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1982436
Cl.[NH2:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](=[O:6])[CH3:5].O.C(=O)([O-])[O-].[K+].[K+].[C:20](Cl)(=[O:26])[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[C:20]([NH:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](=[O:6])[CH3:5])(=[O:26])[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 67340Hexanoyl chlorideHCID 27970031-amino-1-phenylpropan-2-one hydrochloride

Produkt 1

HCID 13293301N-(2-Oxo-1-phenylpropyl)hexanamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a mixture of 1-amino-1-phenyl-2-propanone hydrochloride (5.55 g), water (40 ml), ethyl acetate (75 ml) and potassium carbonate (4.55 g) was added dropwise hexanoyl chloride (4.42 g) under ice-cooling and stirring. The mixture was further stirred for an hour with ice-cooling. The ethyl acetate layer was separated, washed with water, diluted hydrochloric acid and water in that order, and dried over anhydrous magnesium sulfate. The solvent was then distilled off and the residue was recrystallized from isopropyl ether to give crystals of 1-hexanoylamino-1-phenyl-2-propanone, yield 5.80 g (78.2%), m.p. 77°-78° C.

Aufarbeitung

  1. temperaturecooling
  2. stirringThe mixture was further stirred for an hour with ice-
  3. temperaturecooling
  4. customThe ethyl acetate layer was separated
  5. washwashed with water, diluted hydrochloric acid and water in that order
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationThe solvent was then distilled off
  8. customthe residue was recrystallized from isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-839689b51daf449195babcbe1f0eb571
Quelldatensatz
uspto-grants-1986_06
Patentnummer
US04596816

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