Dimethyl Sulfide → 4-(2-Hydroxybenzyl)phenylacetonitrile

HRID 1982821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1982821
FC(F)(F)C(O)=O.CSC.C([O:18][C:19]1[CH:34]=[CH:33][CH:32]=[CH:31][C:20]=1[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29]#[N:30])=[CH:24][CH:23]=1)C1C=CC=CC=1>O>[OH:18][C:19]1[CH:34]=[CH:33][CH:32]=[CH:31][C:20]=1[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29]#[N:30])=[CH:24][CH:23]=1

Komponenten

5

Edukt 3

HCID 1068Dimethyl SulfideHCID 6422Trifluoroacetic acidHCID 21909295[4-(2-Benzyloxybenzyl)phenyl]acetonitrile

Produkt 1

HCID 219092754-(2-Hydroxybenzyl)phenylacetonitrileAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (17 mL), water (1 mL) and dimethyl sulfide (2 mL) were added to [4-(2-benzyloxybenzyl)-phenyl]acetonitrile (0.41 g), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=3/1) to give [4-(2-hydroxybenzyl)phenyl]acetonitrile (0.26 g).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=3/1)

Quellen und Nachweise

ORD-Eintrag
ord-bd9f206cd4a046c799edbdbbd334a03f
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07541341B2

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