Hydrochloric Acid → HCID 69048902, Verbindung

Reaktionsgleichung

[C:1]1([CH2:11][NH:12][S:13]([C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[CH:19][CH:20]=[C:21]3[NH:26]C(=O)C)(=[O:15])=[O:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C(O)CC.[ClH:34]>O>[ClH:34].[NH2:26][C:21]1[CH:20]=[CH:19][CH:18]=[C:17]2[C:22]=1[CH:23]=[CH:24][CH:25]=[C:16]2[S:13]([NH:12][CH2:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)(=[O:15])=[O:14]

Komponenten

Versuchsvorschrift

N-[5-[[[(1-naphthalenyl)methyl]amino]sulfonyl]-1-naphthalenyl]acetamide (226 mg, 0.56 mmol) was suspended in a mixed solution of 1-propanol (8 ml), concentrated hydrochloric acid (1 ml) and water (1 ml), and the mixture was refluxed for 1 hour. The crystal precipitated by cooling of the reaction mixture to room temperature was filtered and washed with the mixed solvent of 1-propanol/diisopropyl ether under reflux to give the title compound an a white crystal (201 mg, 90.8%).