Morpholine → HCID 11281828, Verbindung

HRID 1985865Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1985865
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[CH:11][N:10]([CH2:20][CH2:21][C:22](O)=[O:23])[C:9]2=[S:25])=[CH:4][CH:3]=1.[NH:26]1[CH2:31][CH2:30]O[CH2:28][CH2:27]1>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[CH:11][N:10]([CH2:20][CH2:21][C:22]([N:26]3[CH2:31][CH2:30][CH2:28][CH2:27]3)=[O:23])[C:9]2=[S:25])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 57720839HCID 57720839, Verbindung

Produkt 1

HCID 11281828HCID 11281828, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3-(1-(4-chlorophenyl)-5-(4-fluorophenyl)-1,2-dihydro-2-thioxoimidazol-3-yl)propionic acid (1 eq), 1-3-(dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.7 eq) and morpholine (1.7 eq) in THF is stirred overnight at room temperature. The reaction is quenched with water and extracted with ethyl acetate. The organics are dried and concentrated under vacuum. The residue is purified by chromatography on silica to give 3-(1-(4-chlorophenyl)-5-(4-fluorophenyl)-1,2-dihydro-2-thioxoimidazol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one.

Aufarbeitung

  1. customThe reaction is quenched with water
  2. extractionextracted with ethyl acetate
  3. customThe organics are dried
  4. concentrationconcentrated under vacuum
  5. customThe residue is purified by chromatography on silica

Quellen und Nachweise

ORD-Eintrag
ord-132844b7891e407897ccd7002242bde6
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07547717B2

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