1,5-bis(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinolinone → HCID 57722990, Verbindung

HRID 1987029Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1987029
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17]2[C:12](=[C:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH2:11][CH2:10][C:9]1=[O:27]>ClC1C=CC=CC=1.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17]2[C:12](=[C:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH:11]=[CH:10][C:9]1=[O:27]

Komponenten

4

Edukt 1

HCID 577229821,5-bis(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinolinone

Produkt 1

HCID 57722990HCID 57722990, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 7964ChlorobenzeneLösungsmittel

Versuchsvorschrift

1,5-bis(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinolinone (0.85 g, 2.134 mmol) and manganese dioxide (5 g) were heated in chlorobenzene (50 ml) under reflux for 17 h. After cooling, the chlorobenzene was removed in vacuo, ethyl acetate (80 ml) added to the residue, then filtered through celite. The filtrate was evaporated in vacuo to afford the title compound as a yellow solid (0.82 g, 97%)

Aufarbeitung

  1. temperatureunder reflux for 17 h
  2. temperatureAfter cooling
  3. customthe chlorobenzene was removed in vacuo, ethyl acetate (80 ml)
  4. additionadded to the residue
  5. filtrationfiltered through celite
  6. customThe filtrate was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bb2e8340f4bb4307a8995fc99d2d3f8c
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07550480B2

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