Hydrazine hydrate (1:1) → (2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanohydrazide

Reaktionsgleichung

[F:1][C:2]([F:11])([F:10])[C@:3]([OH:9])([CH3:8])[C:4](OC)=[O:5].O.[NH2:13][NH2:14]>>[F:1][C:2]([F:11])([F:10])[C@:3]([OH:9])([CH3:8])[C:4]([NH:13][NH2:14])=[O:5]

Komponenten

Edukt 2

HCID 24654Hydrazine hydrate (1:1)

HCID 53969069HCID 53969069, Verbindung

Produkt 1

HCID 57729253(2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanohydrazide

Reaktionsbedingungen

Temperatur: 130 °C

Versuchsvorschrift

To a solution of methyl(2S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoate (3.26 g, 19.0 mmol) was added hydrazine monohydrate (2.1 ml). The mixture was heated at 130° C. for 90 min and cooled down to room temperature. After evaporation to dryness, the residue was purified on a small bed of silica gel (100% EtOAc) to afford the title compound.

Aufarbeitung

temperaturecooled down to room temperature
customAfter evaporation to dryness
customthe residue was purified on a small bed of silica gel (100% EtOAc)

Quellen und Nachweise

ORD-Eintrag: ord-f213fe6f37f14c8ebe6353f69db09351
Quelldatensatz: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07553973B2

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